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Funded Project Details - FY2021




Project Number:

I01BX004053-01A2
Title: Impaired methylation alters lipid droplet dynamics in liver and adipose tissue: Role in hepatic steatosis
Principal Investigator:

Kusum K. Kharbanda

Location: Omaha, NE
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $313,124
Total Award Amount
(all years):
$1,614,472
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The development of fatty liver (steatosis) is an early manifestation of alcoholic liver disease (ALD) that can progress to alcoholic hepatitis and cirrhosis with continued alcohol misuse. Hepatic steatosis is a benign and reversible early stage of ALD. However, fat accumulation is regarded as the “first hit” that leaves the liver more vulnerable to multiple hits leading to ALD progression, and is therefore, a prime target for therapeutic intervention. Our long-term objective is to (i) understand...



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