Office of Research & Development |
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Project Number: | I01BX004063-01A2 |
Title: | The role of hyaluronan in hIAPP-induced beta cell toxicity |
Principal Investigator: | Rebecca L Hull-Meichle |
Location: | Seattle, WA |
Congressional District Code: | 9 |
Research Service: | Biomedical Laboratory R&D |
Project Period: | January 2019 - December 2022 |
FY 2023 Funding Amount: | $76,515 |
Total Award Amount (all years): |
$1,216,350 |
Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The pathophysiology of type 2 diabetes (T2D) requires islet β-cell dysfunction in the presence of insulin resistance. Islet amyloid is a pathological feature which occurs in the vast majority of individuals with type 2 diabetes (T2D) and contributes to the β-cell dysfunction and loss that characterizes the disease. Islet amyloid arises due to aggregation of the β-cell peptide islet amyloid polypeptide (IAPP), which is deposited in the islet extracellular matrix (ECM), between β cells and endothe... |