Office of Research & Development |
  |
Talk to the Veterans Crisis Line now
An official website of the United States government
Project Number: | I01BX004063-01A2 |
| Title: | The role of hyaluronan in hIAPP-induced beta cell toxicity |
| Principal Investigator: | Rebecca L Hull-Meichle |
| Location: | Seattle, WA |
| Congressional District Code: | 9 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2019 - December 2022 |
| FY 2023 Funding Amount: | $76,515 |
| Total Award Amount (all years): |
$1,216,350 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The pathophysiology of type 2 diabetes (T2D) requires islet β-cell dysfunction in the presence of insulin resistance. Islet amyloid is a pathological feature which occurs in the vast majority of individuals with type 2 diabetes (T2D) and contributes to the β-cell dysfunction and loss that characterizes the disease. Islet amyloid arises due to aggregation of the β-cell peptide islet amyloid polypeptide (IAPP), which is deposited in the islet extracellular matrix (ECM), between β cells and endothe... |