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Funded Project Details - FY2021

Project Number:

Title: Alcohol-sensitized macrophages enhance colorectal carcinoma metastasis in the liver
Principal Investigator:

Benita L. McVicker

Location: Omaha, NE
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $313,847
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The liver is the terminal site of metastatic disease of colorectal cancer (CRC), that without intervention usually heralds death. The liver is also the main organ affected by alcohol consumption. Interestingly, alcohol use has been identified as a significant risk factor for colorectal liver metastasis (CRLM), yet contributing mechanisms remain undefined. Although alcohol-related CRLM is a serious health concern for the general population, the Veteran population is especially vulnerable because...

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