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Funded Project Details - FY2021

Project Number:

Title: Hormonal Intervention Protects Axon-myelin to Promote Functional Recovery in SCI
Principal Investigator:

Naren Banik

Location: Charleston, SC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $240,495
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Estrogen (E2) treatment is known to be neuroprotectant in spinal cord injury (SCI). This hormone is highly pleiotropic and has been shown to decrease apoptosis, modulate calcium signaling, regulate growth factor expression, act as an anti-inflammatory, and can drive angiogenesis. These beneficial effects were found at the low dose of 10μg/kg E2 (multiple i.v. injections; previous grant), which helped in obtaining IND approval for taking this into a small clinical safety trial. However, the dose...

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