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Funded Project Details - FY2021

Project Number:

Title: Megalin, mitochondrial intracrine signaling and the kidney
Principal Investigator:

David Sheikh-Hamad

Location: Houston, TX
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Mitochondrial dysfunction and reactive oxygen species (ROS) play critical roles in disease processes from ischemic AKI, to immune response and inflammation, diabetes, obesity, metabolic syndrome, aging, neurodegenerative and cardiovascular diseases. Therefore, elucidating mechanisms of mitochondrial dysfunction is key to understanding the pathophysiology of many disease processes. Using the ischemia/reperfusion (I/R) kidney injury model to characterize mitochondrial pathways for kidney protectio...

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