Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government
ORD only    All VA Research websites

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021

Project Number:

Title: PCSK9-A novel target for the treatment of myocardial ischemia
Principal Investigator:

Jawahar L. Mehta

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Mainly expressed in liver, kidney and small intestine, the enzyme proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein-cholesterol receptor (LDLr), and causes degradation of LDLs. Although not proven, it has been suggested that these agents may reduce cardiovascular events. Recent work from our group shows that besides the liver, kidney and small intestine, cardiomyocytes also express PCSK9. The secretion of PCSK9 increases during ischemia by >10 fold. PCSK9...

Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.