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Funded Project Details - FY2021

Project Number:

Title: ATP-Citrate Lyase As A Novel Metabolic Target for Osteoarthritis
Principal Investigator:

Ru Liu Bryan

Location: San Diego, CA
Congressional District Code: 52
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2022
FY 2021 Funding Amount: $305,057
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Aging and obesity are the major risk factors for development of osteoarthritis (OA), the most common form of arthritis. Veterans are at high risk of developing OA, because over 12.4 millions veterans are age 65 or older, and nearly 80% of veterans are obese. For veterans and others, developing effective disease-modifying therapy for OA is a major unmet medical need. As OA progresses, failure of the synovial joint organ frequently develops, with degeneration of articular cartilage as a core disea...

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