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Funded Project Details - FY2021




Project Number:

I01BX002292-05
Title: Structural and biochemical studies of the insulin and IGF1 receptors
Principal Investigator:

W. Todd Miller

Location: Northport, NY
Congressional District Code: 3
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $337,699
Total Award Amount
(all years):
$1,677,875
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Insulin and insulin-like growth factor-1 (IGF1) are closely related polypeptide hormones/growth factors that regulate cell growth and metabolism. Insulin and IGF1 exert their biological effects on target cells by binding to distinct cell surface receptors, the insulin receptor (IR) and the IGF1 receptor (IGF1R), respectively, which are structurally related receptor tyrosine kinases. IR and IGF1R have low basal activity, which is stimulated through ligand binding to the ectodomains, resulting in...



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