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Funded Project Details - FY2021

Project Number:

Title: Selective negative allosteric modulators of alpha 5-GABAA receptors: novel psychotherapeutic drugs
Principal Investigator:

David Morilak

Location: San Antonio, TX
Congressional District Code: 21
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $232,273
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Major depressive disorder (MDD) and posttraumatic stress disorder (PTSD) are highly comorbid, with both having exposure to stressors a contributing factor to their development. They share similarities in treatment with selective serotonin reuptake inhibitors (SSRIs) being the most common pharmacological treatment for both, even though their efficacy is modest. There is a serious unmet need for better treatments for these disorders. The now replicated finding that the NMDA receptor antagonist ket...

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