Funded Project Details - FY2021
|Title:|| Role of mitochondrial dysfunction in hyperoxia-induced pulmonary vascular endothelial injury|
Elizabeth R. Jacobs
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2019 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
More than 250,000 veterans are placed on mechanical ventilation annually. These patients often require high fractions of oxygen (hyperoxia) which significantly exacerbates the injury that triggered mechanical ventilation initially. Pulmonary endothelial cells (PECs) are particularly sensitive to hyperoxia, exhibiting increased production rates of mitochondrially-derived reactive oxygen species (mtROS), mitochondrial (mt) dysfunction, pulmonary edema and ultimately increased morbidity/mortality i...
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