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Funded Project Details - FY2021

Project Number:

Title: Role of mitochondrial dysfunction in hyperoxia-induced pulmonary vascular endothelial injury
Principal Investigator:

Elizabeth R. Jacobs

Location: Milwaukee, WI
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - July 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


More than 250,000 veterans are placed on mechanical ventilation annually. These patients often require high fractions of oxygen (hyperoxia) which significantly exacerbates the injury that triggered mechanical ventilation initially. Pulmonary endothelial cells (PECs) are particularly sensitive to hyperoxia, exhibiting increased production rates of mitochondrially-derived reactive oxygen species (mtROS), mitochondrial (mt) dysfunction, pulmonary edema and ultimately increased morbidity/mortality i...

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