Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01BX003833-01A2
Title: Role of mitochondrial dysfunction in hyperoxia-induced pulmonary vascular endothelial injury
Principal Investigator:

Elizabeth R. Jacobs

Location: Milwaukee, WI
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - July 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$700,731
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

More than 250,000 veterans are placed on mechanical ventilation annually. These patients often require high fractions of oxygen (hyperoxia) which significantly exacerbates the injury that triggered mechanical ventilation initially. Pulmonary endothelial cells (PECs) are particularly sensitive to hyperoxia, exhibiting increased production rates of mitochondrially-derived reactive oxygen species (mtROS), mitochondrial (mt) dysfunction, pulmonary edema and ultimately increased morbidity/mortality i...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.