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Funded Project Details - FY2023

Project Number:

Title: Modulation of Immune Defenses in Pathobiology of CNS Infection
Principal Investigator:

Michal A. Olszewski

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2023 Funding Amount: $69,450
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Objectives: Cryptococcus neoformans is the most important fungal pathogen causing CNS-related mortality and morbidity world-wide. Treatment of C. neoformans CNS infections is very challenging. There is increasing evidence suggesting that paradoxical responses to therapy are mediated by patients’ own immune response to the fungus supported by beneficial effects of anti-inflammatory therapy. However, the use of broad anti- inflammatory (steroid) therapy is controversial because cryptococcosis is p...

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