Funded Project Details - FY2021
|Title:|| Modulation of Immune Defenses in Pathobiology of CNS Infection|
Michal A. Olszewski
||Ann Arbor, MI
|Congressional District Code:
||Biomedical Laboratory R&D
|| January 2019 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
Objectives: Cryptococcus neoformans is the most important fungal pathogen causing CNS-related mortality and morbidity world-wide. Treatment of C. neoformans CNS infections is very challenging. There is increasing evidence suggesting that paradoxical responses to therapy are mediated by patients’ own immune response to the fungus supported by beneficial effects of anti-inflammatory therapy. However, the use of broad anti- inflammatory (steroid) therapy is controversial because cryptococcosis is p...
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