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Funded Project Details - FY2021

Project Number:

Title: The Role of Exogenous Type VII Collagen on the Healing of Skin Wounds
Principal Investigator:

David T. Woodley

Location: Sepulveda, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $156,767
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


We have made the surprising finding that type VII (anchoring fibril) collagen (C7) exogenously administered to murine skin wounds, both topically and intravenously, induces dramatic acceleration of wound closure and the wounds heal with less scarring. This was an unexpected finding because, under normal conditions in unwounded skin, C7 is configured into large structures called anchoring fibrils which are confined to the junction between the dermis and epidermis, the dermal-epidermal junction (D...

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