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Funded Project Details - FY2021

Project Number:

Title: Rotavirus: Studies of the Effectors and Mechanisms of Heterotypic Humoral Immunity in Human Intestinal Epithelial Cells
Principal Investigator:

Harry B. Greenberg

Location: Palo Alto, CA
Congressional District Code: 18
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Rotaviruses (RVs) are the most important cause of severe diarrhea in young children worldwide. These viruses also cause diarrheal disease in healthy adults, the elderly, and the immune compromised. RV replicates primarily in the mature villous tip cells of the small intestine. RVs infect most mammals in a host-specific fashion; in general, RV strains that cause infection in one mammal do not cause disease in another species. Natural RV infection and live attenuated vaccination effectively induce...

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