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Funded Project Details - FY2021




Project Number:

I01BX001955-05
Title: Candida albicans responses to antifungals and cell wall stress
Principal Investigator:

Cornelius J. Clancy

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$710,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Candida albicans causes invasive infections like candidemia and intra-abdominal canididiasis (IAC) that are common among hospitalized patients. The C. albicans cell wall is central to the pathogenesis of candidiasis, but mechanisms that link cell wall regulation and virulence are only beginning to be understood. Cell wall-active echinocandin antifungals are front-line agents against invasive candidiasis. However, mortality rates among patients with candidemia or IAC who are treated with echinoca...



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