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Funded Project Details - FY2021

Project Number:

Title: Role of complement in TBI
Principal Investigator:

Stephen Tomlinson

Location: Charleston, SC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $156,950
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


After initial mechanical insult, traumatic brain injury (TBI) is characterized by a dynamic process of secondary injury that involves chronic neuroinflammation and which is implicated in long-term cognitive and motor impairments. It has long been recognized that neuroinflammation is injurious and represents a therapeutic target for treating TBI. The complement system is a central component of the inflammatory cascade, and while there is increasing evidence that complement plays an important role...

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