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Funded Project Details - FY2021




Project Number:

I01BX004269-01A1
Title: Attenuation of Inflammatory Response in Progressive Neurodegeneration in Parkinson's Disease
Principal Investigator:

Naren Banik

Location: Charleston, SC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $240,495
Total Award Amount
(all years):
$1,249,140
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Parkinson's disease (PD), a progressive degenerative disorder, affects almost 80,000 Veterans. Since there is no cure, new therapies must be developed to halt disease progression. While the mechanisms of this degen- erative process remain elusive, chronic inflammation may be involved. Calpain activates microglia and T cells, induces T cell migration/chemotaxis, plays a pivotal role in spinal cord (SC) degeneration, and may be a driver of inflammation and disease progression. Preliminary data fro...



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