Influence of APOE genotypes on blood brain barrier transport of DHA by mfsd2a in Alzheimer's Disease
Congressional District Code:
Biomedical Laboratory R&D
October 2019 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Over 200,000 US Veterans are suffering from Alzheimer's disease (AD) and this ﬁgure is expected to increase dramatically in the next few decades due to a higher prevalence of traumatic brain injury (TBI) and post- traumatic stress disorder (PTSD) that are risk factors of AD among soldiers returning from Iraq and Afghanistan wars. The apolipoprotein E (APOE) ε4 allele is the most prevalent genetic risk factor for AD, representing 60% of AD subjects in the general population. The apoE protein is a...