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Project Number: | IK2BX004346-01A1 |
| Title: | Optimizing anti-tumor immunity for maximal therapeutic efficacy in Colorectal Cancer |
| Principal Investigator: | Jonathan B Mitchem |
| Location: | Columbia, MO |
| Congressional District Code: | 4 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2018 - September 2023 |
| FY 2021 Funding Amount: | $368,496 |
| Total Award Amount (all years): |
$1,801,406 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Project Summary: Colorectal cancer (CRC) accounts for nearly 10% of all cancer diagnoses in the VA system1. Additionally, the VA system treats 3% of the total number of US cases of CRC and 6% of all US cases in males2. The immune response to CRC is critical to therapeutic response and survival. Cytotoxic T cells (CTL) are the end mediators of the anti-tumor response. As expected, tumor associated CTL are also associated with treatment response and survival in CRC. In our murine model of colorect... |