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Funded Project Details - FY2021

Project Number:

Title: Optimizing anti-tumor immunity for maximal therapeutic efficacy in Colorectal Cancer
Principal Investigator:

Jonathan B Mitchem

Location: Columbia, MO
Congressional District Code: 4
Research Service: Biomedical Laboratory R&D
Project Period: October 2018 - September 2023
FY 2021 Funding Amount: $368,496
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary: Colorectal cancer (CRC) accounts for nearly 10% of all cancer diagnoses in the VA system1. Additionally, the VA system treats 3% of the total number of US cases of CRC and 6% of all US cases in males2. The immune response to CRC is critical to therapeutic response and survival. Cytotoxic T cells (CTL) are the end mediators of the anti-tumor response. As expected, tumor associated CTL are also associated with treatment response and survival in CRC. In our murine model of colorect...

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