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Funded Project Details - FY2021




Project Number:

IK2BX004341-01A1
Title: Understanding how DOPA decarboxylase modulates tau in disease
Principal Investigator:

Rebecca Kow

Location: Seattle, WA
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2023
FY 2021 Funding Amount: $194,631
Total Award Amount
(all years):
$971,862
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Background: Neurodegenerative diseases with tau pathology (tauopathies) include Alzheimer's disease and chronic traumatic encephalopathy. Two major risk factors for developing tauopathies are aging and repetitive mild traumatic brain injury. The prevalence of tauopathies is expected to rise, especially among Veterans. However, there are no clinically-approved treatments for tauopathies. DOPA decarboxylase, the second enzyme in dopamine and serotonin synthesis, was recently identified as a novel...



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