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Funded Project Details - FY2021




Project Number:

IK2BX003841-01A2
Title: Role of p73 in COPD Pathogenesis
Principal Investigator:

Bradley W Richmond

Location: Nashville, TN
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: January 2019 - December 2023
FY 2021 Funding Amount: $294,870
Total Award Amount
(all years):
$1,560,120
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and has no cure. While the association between chronic tobacco smoke exposure and COPD has been known for decades, the reasons for ongoing lung damage in COPD after smoking cessation remain undefined. We and others have shown that epithelial remodeling with loss of multiciliated cells (MCCs) is widespread in the airways of COPD patients and abnormal epithelial differentiation in...



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