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Funded Project Details - FY2021

Project Number:

Title: Pharmacological and toxicological testing of a novel L-asparaginase
Principal Investigator:

Arnon Lavie

Location: Chicago, IL
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $260,845
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Project Summary: The goal of this proposal is to perform IND-enabling studies of a significantly safer variant of the anti-cancer biologic drug L-asparaginase. L-asparaginases are enzyme drugs that act to deplete the amino acid asparagine from the blood. Due to toxicity, which is especially pronounced in adults, L- asparaginase treatment is limited to acute lymphoblastic leukemia (ALL), a cancer of white blood cells. One source of toxicity of L-asparaginases is due to their bacterial origin (eit...

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