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Funded Project Details - FY2021




Project Number:

I01BX004588-01
Title: High-dose targeted and non-toxic IL-2 cytokine therapy
Principal Investigator:

Alexander S Krupnick

Location: Baltimore, MD
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$310,850
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT SUMMARY/ABSTRACT Systemic administration of high-dose IL-2 has been used since the 1980’s as an FDA-approved immunotherapy for metastatic cancer. Despite the fact that up to 9% of patients treated with high dose IL-2 achieve a durable, long term response, this therapy is rarely used today due to significant life-threatening complications. Such complications occur due to IL-2 activation of vascular endothelium, resulting in systemic capillary leak, as well as other adverse effects associ...



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