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Project Number: | I01CX001715-01A2 |
| Title: | Pulmonary fibrosis is modulated by MCU-mediated macrophage apoptosis resistance |
| Principal Investigator: | A. Brent Carter |
| Location: | Birmingham, AL |
| Congressional District Code: | 7 |
| Research Service: | Clinical Science R&D |
| Project Period: | January 2019 - December 2022 |
| FY 2021 Funding Amount: | $144,000 |
| Total Award Amount (all years): |
$713,750 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: ! In fibrotic disorders of the lung, including idiopathic pulmonary fibrosis (IPF), lung macrophages have a decisive role in fibrotic repair of injured lung. Macrophages play an integral role in the normal resolution of organ injury but also contribute to the pathogenesis of pulmonary fibrosis by initiating an immune response and by generating reactive oxygen species (ROS), particularly mitochondrial ROS (mtROS). Lung remodeling during pulmonary fibrosis is poorly understood; however, changes in... |