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Funded Project Details - FY2021

Project Number:

Title: Pulmonary fibrosis is modulated by MCU-mediated macrophage apoptosis resistance
Principal Investigator:

A. Brent Carter

Location: Birmingham, AL
Congressional District Code: 7
Research Service: Clinical Science R&D
Project Period: January 2019 - December 2022
FY 2021 Funding Amount: $144,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


! In fibrotic disorders of the lung, including idiopathic pulmonary fibrosis (IPF), lung macrophages have a decisive role in fibrotic repair of injured lung. Macrophages play an integral role in the normal resolution of organ injury but also contribute to the pathogenesis of pulmonary fibrosis by initiating an immune response and by generating reactive oxygen species (ROS), particularly mitochondrial ROS (mtROS). Lung remodeling during pulmonary fibrosis is poorly understood; however, changes in...

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