Funded Project Details - FY2021
|Title:|| Pulmonary fibrosis is modulated by MCU-mediated macrophage apoptosis resistance|
A. Brent Carter
|Congressional District Code:
||Clinical Science R&D
|| January 2019 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER
! In fibrotic disorders of the lung, including idiopathic pulmonary fibrosis (IPF), lung macrophages have a decisive role in fibrotic repair of injured lung. Macrophages play an integral role in the normal resolution of organ injury but also contribute to the pathogenesis of pulmonary fibrosis by initiating an immune response and by generating reactive oxygen species (ROS), particularly mitochondrial ROS (mtROS). Lung remodeling during pulmonary fibrosis is poorly understood; however, changes in...
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