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Funded Project Details - FY2021




Project Number:

I01BX001966-05
Title: Thyroid Hormone and Neuronal Protection
Principal Investigator:

Gregory A. Brent

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$710,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Thyroid hormone (TH) is essential for normal brain development and may also promote recovery and neuronal regeneration after brain injury. TH acts predominantly through the nuclear receptors, TH receptor alpha (THRA) and beta (THRB). Additional factors that impact TH action in the brain include metabolism, activation of thyroxine (T4) to triiodothyronine (T3) by the enzyme 5′-deiodinase Type 2 (Dio2), inactivation by the enzyme 5-deiodinase Type 3 (Dio3) to reverse T3 (rT3), which occurs in glia...



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