Type I Interferon Regulation of PD-L1 Expression and Function in MDSCs
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Clinical Science R&D
January 2019 -
FY 2021 Funding Amount:
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Project Abstract Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells (IMCs). Under physiological conditions, IMCs quickly differentiate into mature granulocytes, macrophages or dendritic cells. By contrast, under pathological conditions, a partial block of IMC differentiation into mature myeloid cells results in the expansion and activation of this population. In human cancer patients, massive accumulation of MDSCs is a hallmark of cancer progressio...