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Funded Project Details - FY2021

Project Number:

Title: Targeting Sphinogsine-1-phosphate to overcome SNAI1-mediated therapy resistance in rectal cancer
Principal Investigator:

E. Ramsey Camp

Location: Houston, TX
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: January 2019 - December 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


For over fourteen years, neoadjuvant 5-fluorouracil chemoradiation (5FU/RT) has remained the standard option for patients with rectal cancer (RC), a deadly cancer in our veterans. Unfortunately, therapeutic resistance is evident in ~80% of these cases, increasing the chances of surgical failure, disease recurrence, and ultimately, death. These issues highlight the current lack of effective therapeutic strategies required to advance care due, in part, to the lack of clinically relevant RC researc...

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