Talk to the Veterans Crisis Line now
U.S. flag
An official website of the United States government

Office of Research & Development

print icon sign up for VA Research updates

Funded Project Details - FY2021




Project Number:

I01CX001880-01A1
Title: Targeting Sphinogsine-1-phosphate to overcome SNAI1-mediated therapy resistance in rectal cancer
Principal Investigator:

E. Ramsey Camp

Location: Houston, TX
Congressional District Code: 1
Research Service: Clinical Science R&D
Project Period: January 2019 - December 2023
FY 2021 Funding Amount: $0
Total Award Amount
(all years):
$657,600
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

For over fourteen years, neoadjuvant 5-fluorouracil chemoradiation (5FU/RT) has remained the standard option for patients with rectal cancer (RC), a deadly cancer in our veterans. Unfortunately, therapeutic resistance is evident in ~80% of these cases, increasing the chances of surgical failure, disease recurrence, and ultimately, death. These issues highlight the current lack of effective therapeutic strategies required to advance care due, in part, to the lack of clinically relevant RC researc...



Questions about the R&D website? Email the Web Team.

Any health information on this website is strictly for informational purposes and is not intended as medical advice. It should not be used to diagnose or treat any condition.