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Funded Project Details - FY2021

Project Number:

Title: Microbiologic impact of medical therapies for recurrent Clostridium difficile infection
Principal Investigator:

Curtis J. Donskey

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Clinical Science R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $165,000
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Approximately 25% of patients responding to treatment for initial cases of Clostridium difficile infection (CDI) develop a recurrence of the infection, and many develop multiple recurrences. Unfortunately, the optimal medical management of recurrent CDI is unclear. In particular, vancomycin taper and pulse regimens are commonly used, but have not been compared to other medical treatments in randomized trials. To address this deficiency, the VA Cooperative Studies Program (CSP) is conducting a ra...

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