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Funded Project Details - FY2023

Project Number:

Title: Targeting Burkholderial β-lactamases: Structure, function, and regulation
Principal Investigator:


Location: Cleveland, OH
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2023 Funding Amount: $322,277
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The prevalence of the Burkholderia cepacia complex (Bcc), a group of multidrug-resistant (MDR) pathogens, is predicted to significantly increase in patients with pulmonary disorders (e.g., chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and asthma) by 2024. Moreover, MDR Bcc isolates that are resistant to all currently recommended therapies are emerging. Unfortunately, the development of novel drugs against MDR Bcc is lacking as is our understanding of these unique pathogens....

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