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Funded Project Details - FY2021




Project Number:

I01BX002872-05
Title: Targeting Burkholderial β-lactamases: Structure, function, and regulation
Principal Investigator:

KRISZTINA M PAPP

Location: Cleveland, OH
Congressional District Code: 11
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $294,832
Total Award Amount
(all years):
$1,458,067
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

The prevalence of the Burkholderia cepacia complex (Bcc), a group of multidrug-resistant (MDR) pathogens, is predicted to significantly increase in patients with pulmonary disorders (e.g., chronic obstructive pulmonary disease (COPD), cystic fibrosis (CF), and asthma) by 2024. Moreover, MDR Bcc isolates that are resistant to all currently recommended therapies are emerging. Unfortunately, the development of novel drugs against MDR Bcc is lacking as is our understanding of these unique pathogens....



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