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Funded Project Details - FY2021

Project Number:

Title: HDL as a therapeutic target for sepsis
Principal Investigator:

Xiang-An Li

Location: Lexington, KY
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $232,064
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Sepsis is a major health issues for public and for veterans. A recent study conducted in 118 VA hospitals showed that 4.1% of patients undergoing surgery developed postoperative sepsis. The mortality rate of sepsis is high, exceeding 30%, due to a lack of efficient therapy. A great barrier for sepsis therapy is that sepsis is a multi-factor disease, involving endotoxin from bacteria, dysregulated response in immune effector cells, all of which lead to cell damage and endothelial dysfunction, res...

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