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Funded Project Details - FY2021

Project Number:

Title: Neutrophil Polarization Following Myocardial Infarction
Principal Investigator:

Merry L Lindsey

Location: Omaha, NE
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $247,422
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract About one in four myocardial infarction (MI) patients progress to develop congestive heart failure, which has a 5-year mortality rate of 50%. The goal of this project is to understand post-MI roles of neutrophils by establishing how this cell type transitions in phenotype during wound healing spanning from inflammation to repair. We hypothesize that neutrophils undergo a temporal phenotype evolution that includes influencing post-MI inflammation resolution and ECM organization. Specifi...

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