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Funded Project Details - FY2021

Project Number:

Title: Novel mechanisms for Alzheimer disease prevention and or treatment
Principal Investigator:

Luigi Puglielli

Location: Madison, WI
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $156,784
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


PROBLEM: Aging is the most important risk factor for Alzheimer's disease (AD), which represents the most common cause of dementia in our country. The disease, for which there is no currently available treatment, is becoming increasingly prevalent among our aging veteran population. PRELIMINARY DATA: Autophagy is an essential component of the cell degrading machinery. It helps dispose of large toxic protein aggregates that form within the secretory pathway and in the cytosol. Malfunction of auto...

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