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Funded Project Details - FY2021




Project Number:

I01BX004275-01A1
Title: Mechanisms linking obesity and abdominal aortic aneurysm
Principal Investigator:

Lisa R Tannock

Location: Lexington, KY
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$700,683
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Obesity has emerged as a risk factor for human and angiotensin II (AngII)-induced abdominal aortic aneurysms (AAA). Obesity is highly prevalent in Veterans; the Veteran population also has high prevalence of other risk factors for AAAs (male sex, smoking, hypertension). To date, no single therapy has proven effective to blunt progressive growth of AAAs, likely due to diverse etiologies underlying AAAs in the human population. Thus, therapies must be individualized to target the relevant risk fac...



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