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Funded Project Details - FY2021




Project Number:

I01BX004626-01
Title: Controlling FKBP51 for the treatment of PTSD
Principal Investigator:

Laura J. Blair

Location: Tampa, FL
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $232,064
Total Award Amount
(all years):
$1,086,311
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

U.S. Veterans are at increased risk for developing psychiatric symptoms and disorders compared to the civilian population. The hypothalamic-pituitary-adrenal (HPA) axis has long been linked to stress-induced psychiatric disorders. The 51kDa FK506-binding protein, FKBP51, together with the 90kDa heat shock protein (Hsp90), regulates the activity of steroid hormone complexes in the HPA axis and other cascades. The FKBP51-chaperone complex slows the response of the HPA axis to circulating stress ho...



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