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Funded Project Details - FY2021

Project Number:

Title: Microglia in White Matter Repair after TBI
Principal Investigator:

Dandan Sun

Location: Pittsburgh, PA
Congressional District Code: 14
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $186,392
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Traumatic brain injury (TBI) affects more than 2.5 million (US civilian and veterans) annually and accounts for 30% of all injury-related fatalities. TBI patients often develop long-lasting traumatic axonal injury, loss of myelin sheath, and inhibition of oligodendrocyte maturation, which contribute to motor, cognitive, behavioral, and psychiatric deficits. However, the underlying mechanisms of TBI-induced white matter injury and impairment of axonal remyelination remain poorly understood. Micro...

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