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Project Number: | I01BX004625-01 |
| Title: | Microglia in White Matter Repair after TBI |
| Principal Investigator: | Dandan Sun |
| Location: | Pittsburgh, PA |
| Congressional District Code: | 14 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $186,392 |
| Total Award Amount (all years): |
$783,725 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Traumatic brain injury (TBI) affects more than 2.5 million (US civilian and veterans) annually and accounts for 30% of all injury-related fatalities. TBI patients often develop long-lasting traumatic axonal injury, loss of myelin sheath, and inhibition of oligodendrocyte maturation, which contribute to motor, cognitive, behavioral, and psychiatric deficits. However, the underlying mechanisms of TBI-induced white matter injury and impairment of axonal remyelination remain poorly understood. Micro... |