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Funded Project Details - FY2021

Project Number:

Title: Regulation of Detrusor Overactivity by Cellular Stress in Bladder Ischemia
Principal Investigator:

Kazem M. Azadzoi

Location: Boston, MA
Congressional District Code: 7
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $362,790
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The overall goal of this renewal research proposal is to determine the role of ischemia in the development of detrusor overactivity in the non-obstructed bladder. Another goal is to examine the efficacy of targeting cellular stress response pathways to prevent or reverse bladder dysfunction. Lower urinary tract symptoms (LUTS) are bothersome constellation of voiding symptoms with significant impact on quality of life. The prevalence of bladder dysfunction and LUTS among Veterans is almost five f...

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