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Funded Project Details - FY2021

Project Number:

Title: Targeting Molecular Transducers of Exercise for Osteoarthritis Therapies
Principal Investigator:

Timothy M Griffin

Location: Oklahoma City, OK
Congressional District Code: 5
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $256,002
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Osteoarthritis (OA) disproportionately affects veterans, resulting in more pain and functional limitations compared to the general population. No disease-modifying treatments exist for OA, and current pain medications (e.g., opioids and NSAIDs) have limited long-term efficacy and adverse side effects. Unresolved cellular and molecular joint inflammation is recognized as the central mechanism of OA progression. However, a barrier to progress in the field is identifying the causes of chronic OA in...

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