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Funded Project Details - FY2021




Project Number:

I01BX002003-05A2
Title: Functions of Leptospira Lig Proteins in the Pathogenesis of Leptospirosis
Principal Investigator:

David A. Haake

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $156,765
Total Award Amount
(all years):
$674,861
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Leptospirosis is a neglected global human health problem caused by transmission from reservoir hosts that harbor pathogenic Leptospira species in their kidneys and shed them into the environment via their urine. Our goal is to elucidate the role(s) of the surface-exposed leptospiral immunoglobulin- like (Lig) proteins in mechanisms of leptospiral pathogenesis and immunity. The LigA and LigB proteins exhibit high affinity binding to host ligands and inhibit complement activation, trigger plasmino...



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