Funded Project Details - FY2021
|Title:|| Functions of Leptospira Lig Proteins in the Pathogenesis of Leptospirosis|
David A. Haake
||West Los Angeles, CA
|Congressional District Code:
||Biomedical Laboratory R&D
|| April 2019 -
|FY 2021 Funding Amount:
|Total Award Amount
View full abstract and other project information on NIH RePORTER
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Leptospirosis is a neglected global human health problem caused by transmission from reservoir hosts that harbor pathogenic Leptospira species in their kidneys and shed them into the environment via their urine. Our goal is to elucidate the role(s) of the surface-exposed leptospiral immunoglobulin- like (Lig) proteins in mechanisms of leptospiral pathogenesis and immunity. The LigA and LigB proteins exhibit high affinity binding to host ligands and inhibit complement activation, trigger plasmino...
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