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Project Number: | I01BX004661-01 |
| Title: | MAVS-Mediated Pulmonary Inflammation and Injury Response During Cigarette Smoke Exposure and Influenza Viral Infection and in COPD |
| Principal Investigator: | Charles Dela Cruz |
| Location: | West Haven, CT |
| Congressional District Code: | 3 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $156,800 |
| Total Award Amount (all years): |
$701,800 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Viral infections have more severe consequences in individuals who have been exposed to cigarette smoke (CS) than in those not exposed to CS. Acute exacerbations of COPD contributes toward rapid lung function decline. Surprisingly, the mechanisms that underlie the exaggerated virus-induced responses in CS-exposed individuals have not been adequately addressed. Our studies demonstrated that viruses cause increased levels of inflammation, tissue destruction and lung fibrosis in CS exposed mice. We... |