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Funded Project Details - FY2021




Project Number:

I01BX004272-01A2
Title: Signals controlling tissues homeostasis in the ovary
Principal Investigator:

John S. Davis

Location: Omaha, NE
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $254,200
Total Award Amount
(all years):
$807,400
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Recent developments in other fields of research have shed light on an evolutionarily conserved pathway that controls organ size by regulating cell proliferation, apoptosis, and stem cell self-renewal. This pathway is called the Hippo signaling pathway and disrupting the Hippo pathway results in the loss of tissue homeostasis and contributes to many human diseases. Despite extensive study of the Hippo pathway in the past decade, the exact nature of extracellular signals and membrane receptors reg...



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