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Project Number: | I01BX004651-01 |
| Title: | Reactivating p53 Function with a Novel Structure-based Peptide as a Therapeutic Approach for Overcoming Platinum Resistance |
| Principal Investigator: | Sanaz Memarzadeh |
| Location: | West Los Angeles, CA |
| Congressional District Code: | 33 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | January 2020 - December 2023 |
| FY 2021 Funding Amount: | $156,733 |
| Total Award Amount (all years): |
$709,425 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Treatments that restore p53 activity could provide a breakthrough in cancer therapy given that p53 is mutated in many cancers. Successful targeting of p53 is an unmet clinical need evidenced by the lack of FDA-approved drugs in this category. We have collaboratively developed and tested ReACp53, a peptide that re-enables p53 function by preventing its aggregation. Our previous work demonstrated the efficacy of ReACp53 monotherapy in targeting high-grade serous ovarian cancers (HGSOCs), which are... |