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Funded Project Details - FY2021




Project Number:

I01BX004333-01A1
Title: Novel Complement-targeted treatment strategies in Renal Disease
Principal Investigator:

Elias Lianos

Location: Salem, VA
Congressional District Code: 9
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $155,902
Total Award Amount
(all years):
$706,408
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

PROJECT SUMMARY / ABSTRACT The glomerular microvasculature is a common target of dysregulated or pathologic complement (C) activation. This has been implicated in the pathogenesis of a wide range of glomerulopathies including lupus nephritis, membranoproliferative glomerulopathy, postinfectious glomerulonephritis and, more recently, the atypical Hemolytic Uremic Syndrome (aHUS), and C3 glomerulopathy. Therefore, development of strategies to minimize activation of C cascades could be promising i...



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