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Project Number: | I01BX004768-01 |
| Title: | Therapeutic Targeting of MDS Stem Cells |
| Principal Investigator: | Craig T. Jordan |
| Location: | Denver, CO |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2020 - March 2024 |
| FY 2021 Funding Amount: | $264,084 |
| Total Award Amount (all years): |
$1,242,857 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: The goal of this application is to elucidate properties of myelodysplastic syndrome (MDS) stem cells that will lead to improved strategies for therapeutic targeting. In the context of MDS, malignant stem cells are thought to reside at the heart of disease, driving progression and ultimately transformation to acute myeloid leukemia (AML). While some drugs have activity in MDS, few if any clinically approved agents are known to efficiency eradicate MDS stem cells. Thus, our studies have focused on... |