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Funded Project Details - FY2021

Project Number:

Title: Therapeutic Targeting of MDS Stem Cells
Principal Investigator:

Craig T. Jordan

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: April 2020 - March 2024
FY 2021 Funding Amount: $264,084
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


The goal of this application is to elucidate properties of myelodysplastic syndrome (MDS) stem cells that will lead to improved strategies for therapeutic targeting. In the context of MDS, malignant stem cells are thought to reside at the heart of disease, driving progression and ultimately transformation to acute myeloid leukemia (AML). While some drugs have activity in MDS, few if any clinically approved agents are known to efficiency eradicate MDS stem cells. Thus, our studies have focused on...

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