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Funded Project Details - FY2021




Project Number:

I01BX004565-01A1
Title: Neutrophil heterogeneity and function in host defense during pulmonary infection
Principal Investigator:

Jane C Deng

Location: Ann Arbor, MI
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
$690,000
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Secondary bacterial pneumonias complicating influenza and respiratory viral infections are more severe than primary pneumonias and often fatal, but why this occurs is unclear. Our data demonstrate that neutrophils, which are the most abundant white blood cell and critical for fighting bacterial infections, from influenza-infected animals display impaired ability to ingest and kill bacteria, compared to neutrophils from uninfected and bacteria-infected animals. To date, neutrophils have been larg...



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