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Project Number: | I01BX004280-01A2 |
| Title: | Targeting the in Vivo Hypoxic Microenvironment of Multiple Myeloma as an Anti-Tumor Strategy |
| Principal Investigator: | Patrick J. Frost |
| Location: | West Los Angeles, CA |
| Congressional District Code: | 33 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2021 Funding Amount: | $307,148 |
| Total Award Amount (all years): |
$1,401,915 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Multiple myeloma (MM) is a disease of the hematological system in which plasma cells that have developed malignant characteristics engraft within the bone marrow (BM). There is a consensus that the microenvironment of the BM contains factors and conditions that play a major role in the myeloma survival and proliferation. The BM is known to be hypoxic (pO2~<32mmHg) and low pO2 is theoretically deleterious to the survival of MM and other cells, although myeloma cells have developed adaptive respon... |