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Funded Project Details - FY2021

Project Number:

Title: Targeting the in Vivo Hypoxic Microenvironment of Multiple Myeloma as an Anti-Tumor Strategy
Principal Investigator:

Patrick J. Frost

Location: West Los Angeles, CA
Congressional District Code: 33
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $307,148
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Multiple myeloma (MM) is a disease of the hematological system in which plasma cells that have developed malignant characteristics engraft within the bone marrow (BM). There is a consensus that the microenvironment of the BM contains factors and conditions that play a major role in the myeloma survival and proliferation. The BM is known to be hypoxic (pO2~<32mmHg) and low pO2 is theoretically deleterious to the survival of MM and other cells, although myeloma cells have developed adaptive respon...

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