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Funded Project Details - FY2021

Project Number:

Title: Exploring Alzheimer Therapeutics
Principal Investigator:

Weiming Xia

Location: Bedford, MA
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: January 2020 - December 2023
FY 2021 Funding Amount: $156,800
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Abstract This project will advance the re-positioning of a novel therapeutic agent, fasudil, for the treatment of Alzheimer’s disease (AD). Currently there is a huge unmet need for safe and effective disease modifying therapies to treat and prevent AD. This study will generate preclinical pharmacological outcomes to prepare for the USA FDA application for AD clinical trials and extend our studies of the mechanism of action (MOA) of fasudil in cells and the 3X-Tg AD mouse model of disease. Both...

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