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Project Number: | I01BX000740-09 |
| Title: | Right Heart Function in Health and Chronic Disease |
| Principal Investigator: | Anthony J. Baker |
| Location: | San Francisco, CA |
| Congressional District Code: | 12 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | October 2019 - September 2023 |
| FY 2021 Funding Amount: | $320,581 |
| Total Award Amount (all years): |
$1,770,451 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Right ventricular failure (RVF) is a serious clinical problem with a poor prognosis. However, specific treatment options for RVF are very limited. Recent studies suggest that powerful cardioprotective effects are mediated by α1-adrenergic receptors, in particular the α1A-subtype (α1A-AR). In the current funding period, we found that chronic stimulation of α1A-ARs had major beneficial effects on RV function in two mouse models of RVF induced by pulmonary fibrosis or pulmonary artery constriction... |