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Funded Project Details - FY2021

Project Number:

Title: Right Heart Function in Health and Chronic Disease
Principal Investigator:

Anthony J. Baker

Location: San Francisco, CA
Congressional District Code: 12
Research Service: Biomedical Laboratory R&D
Project Period: October 2019 - September 2023
FY 2021 Funding Amount: $320,581
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Right ventricular failure (RVF) is a serious clinical problem with a poor prognosis. However, specific treatment options for RVF are very limited. Recent studies suggest that powerful cardioprotective effects are mediated by α1-adrenergic receptors, in particular the α1A-subtype (α1A-AR). In the current funding period, we found that chronic stimulation of α1A-ARs had major beneficial effects on RV function in two mouse models of RVF induced by pulmonary fibrosis or pulmonary artery constriction...

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