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Funded Project Details - FY2021




Project Number:

I01BX003901-01A2
Title: Role of Natural Antibodies Against Oxidation Specific Epitopes in Bone Homeostasis
Principal Investigator:

Elena Ambrogini

Location: Little Rock, AR
Congressional District Code: 2
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $156,593
Total Award Amount
(all years):
$686,172
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Lipid peroxidation forms highly reactive molecules that generate adducts with amino groups of proteins and lipids, known as oxidation specific epitopes (OSEs). OSEs are ubiquitous pro-inflammatory moieties that cause extensive cell damage if not promptly eliminated. Natural antibodies of the innate immune system, recognize OSEs and block their adverse effects. Scavenger receptors (SRs) expressed in macrophages and other cell types recognize OSEs and dispose of oxidatively-modified endogenous mol...



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