Regulation of Cellular Phenotype Change in Thoracic Aortic Aneurysms
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Biomedical Laboratory R&D
April 2019 -
FY 2021 Funding Amount:
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View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt:
Thoracic aortic aneurysms (TAAs) develop as a consequence to abnormal remodeling of the aortic extracellular matrix (ECM).10 This usually asymptomatic process results in a weakened aortic wall manifested as gross dilatation that progresses to rupture. Current treatment includes blood pressure management until the risk of rupture outweighs the risk of surgical or endovascular intervention; neither of which address the underlying pathways which drive this devastating disease.11 TAA development is...