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Project Number: | I01BX000904-08A1 |
| Title: | Regulation of Cellular Phenotype Change in Thoracic Aortic Aneurysms |
| Principal Investigator: | Jeffrey Jones |
| Location: | Charleston, SC |
| Congressional District Code: | 1 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | April 2019 - March 2023 |
| FY 2021 Funding Amount: | $313,335 |
| Total Award Amount (all years): |
$1,521,135 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Thoracic aortic aneurysms (TAAs) develop as a consequence to abnormal remodeling of the aortic extracellular matrix (ECM).10 This usually asymptomatic process results in a weakened aortic wall manifested as gross dilatation that progresses to rupture. Current treatment includes blood pressure management until the risk of rupture outweighs the risk of surgical or endovascular intervention; neither of which address the underlying pathways which drive this devastating disease.11 TAA development is... |