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Funded Project Details - FY2021

Project Number:

Title: Regulation of Cellular Phenotype Change in Thoracic Aortic Aneurysms
Principal Investigator:

Jeffrey Jones

Location: Charleston, SC
Congressional District Code: 1
Research Service: Biomedical Laboratory R&D
Project Period: April 2019 - March 2023
FY 2021 Funding Amount: $313,335
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Thoracic aortic aneurysms (TAAs) develop as a consequence to abnormal remodeling of the aortic extracellular matrix (ECM).10 This usually asymptomatic process results in a weakened aortic wall manifested as gross dilatation that progresses to rupture. Current treatment includes blood pressure management until the risk of rupture outweighs the risk of surgical or endovascular intervention; neither of which address the underlying pathways which drive this devastating disease.11 TAA development is...

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