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Funded Project Details - FY2021

Project Number:

Title: Regulation of Targeted Therapeutic Response by the Immune Microenvironment in HNSCC
Principal Investigator:

Lynn Heasley

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $250,322
Total Award Amount
(all years):
Abstract: View full abstract and other project information on NIH RePORTER


Despite optimized therapeutic regimens, the 5-year survival rate for head and neck squamous cell carcinoma (HNSCC) remains around 50%. EGFR is a key component of a receptor tyrosine kinase (RTK) network that functions as a non-mutated “driver” in HNSCC cell lines and is the target for the FDA-approved agent, cetuximab. Individually, HNSCC patients exhibit wide-ranging extent of response to cetuximab as well as ERBB family- targeted tyrosine kinase inhibitors (TKIs) such as afatinib. Importantly,...

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