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Project Number: | I01BX004480-01A1 |
| Title: | SIRT3 Deficiency-mediated Metabolic Dysregulation in Comorbid Alzheimer's Disease |
| Principal Investigator: | Subbiah Pugazhenthi |
| Location: | Denver, CO |
| Congressional District Code: | 6 |
| Research Service: | Biomedical Laboratory R&D |
| Project Period: | July 2019 - June 2023 |
| FY 2023 Funding Amount: | $293,426 |
| Total Award Amount (all years): |
$1,449,361 |
| Abstract: |
View full abstract and other project information on NIH RePORTER Go To NIH RePORTER Excerpt: Alzheimer's disease (AD), the most frequent cause of dementia, is characterized by accumulation of amyloid plaques and formation of neurofibrillary tangles. Treatment of AD is a challenge because this devastating disease often coexists with other brain lesions caused by comorbidities, including obesity, diabetes, hypertension and cardiovascular diseases. Metabolic syndrome (MetS) is the early stage of these comorbidities and it is prevalent among veteran population. MetS in mid-life could intera... |