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Funded Project Details - FY2021




Project Number:

I01BX004480-01A1
Title: SIRT3 Deficiency-mediated Metabolic Dysregulation in Comorbid Alzheimer's Disease
Principal Investigator:

Subbiah Pugazhenthi

Location: Denver, CO
Congressional District Code: 6
Research Service: Biomedical Laboratory R&D
Project Period: July 2019 - June 2023
FY 2021 Funding Amount: $306,443
Total Award Amount
(all years):
$1,427,159
Abstract: View full abstract and other project information on NIH RePORTER
Go To NIH RePORTER


Excerpt:

Alzheimer's disease (AD), the most frequent cause of dementia, is characterized by accumulation of amyloid plaques and formation of neurofibrillary tangles. Treatment of AD is a challenge because this devastating disease often coexists with other brain lesions caused by comorbidities, including obesity, diabetes, hypertension and cardiovascular diseases. Metabolic syndrome (MetS) is the early stage of these comorbidities and it is prevalent among veteran population. MetS in mid-life could intera...



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